Fig. 3

5FU treatment induces variable gene expression response in HT29 cells cultured in colorectal PDS. A 5FU-induced gene expression fingerprint. Dots represent 5FU response in individual PDS relative to the respective untreated PDS controls. Red bars indicate Mean ± SD (n = 89). *p < 0.05; **p < 0.01 (untreated PDS vs 5FU-treated PDS, Mann–Whitney U test). B Heatmaps representing Spearman’s rank correlation coefficients of (i) 5FU-induced gene expression fingerprint and (ii) between PDS- and 5FU-induced gene expression fingerprint