Parameter | Univariate | Two-variable | Multivariablea | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variable | Timepoint | Value | p | HR | Lower HR | Upper HR | p | HR | Lower HR | Upper HR | p | HR | Lower HR | Upper HR |
Platelets | Basal | + 10,000 | 0.419 | 1.007 | 0.900 | 1.025 | – | – | – | – | ||||
Δ | Ref ≤ 25,000 | 0.039 | 1.398 | 1.016 | 1.922 | 0.116 | 1.310 | 0.935 | 1.836 | |||||
White blood cell count | Basal | + 100 | 0.001 | 1.006 | 1.002 | 1.010 | 0.069 | 0.990 | 0.979 | 1.001 | ||||
Δ | Ref ≤ 1920 | < 0.001 | 2.063 | 1.396 | 3.049 | – | – | – | – | |||||
Neutrophils | Basal | + 100 | < 0.001 | 1.011 | 1.007 | 1.015 | 0.003 | 1.022 | 1.008 | 1.037 | ||||
Δ | Ref ≤ 310 | 0.020 | 1.429 | 1.058 | 1.930 | – | – | – | – | |||||
Lymphocytes | Basal | + 100 | 0.054 | 0.981 | 0.962 | 1.000 | – | – | – | – | ||||
Δ | Ref ≥ -300 | < 0.001 | 1.910 | 1.356 | 2.692 | – | – | – | – | |||||
NL ratio | Basal | + 1 | < 0.001 | 1.176 | 1.078 | 1.284 | – | – | – | – | ||||
Δ | Ref ≤ 0.86 | < 0.001 | 1.975 | 1.411 | 2.764 | 0.004 | 1.709 | 1.183 | 2.468 | |||||
PL ratio | Basal | + 1 | 0.156 | 1.001 | 0.999 | 1.003 | – | – | – | – | ||||
Δ | Ref ≤ 22.85 | 0.001 | 1.693 | 1.240 | 2.311 | – | – | – | – | |||||
Age | Basal | + 1 | 0.210 | 1.007 | 0.996 | 1.019 | – | – | – | – | ||||
Sex | Basal | Ref F | 0.601 | 0.923 | 0.682 | 1.248 | – | – | – | – | ||||
Number of metastatic sites | Basal | Ref ≥ 3 | 0.013 | 0.686 | 0.509 | 0.925 | – | – | – | – | ||||
LDH | Basal | Ref elevated | 0.001 | 0.581 | 0.420 | 0.803 | 0.070 | 0.729 | 0.518 | 1.026 |