Clinical validation of a 90-gene expression test for tumor tissue of origin diagnosis: a large-scale multicenter study of 1417 patients

Table 1 Patient and tumor demographics and specimen sources

Characteristics	Number of specimens (N = 1417)	Percentage (%)
Study
Retrospective	924	65.2
Prospective	493	34.8
Centers
BCH	518	36.6
FUSCC	424	29.9
ZCH	475	33.5
Age (year)
Median	57
Range	9–88
Gender
Male	673	47.5
Female	744	52.5
Histological type
Adenocarcinoma	943	66.5
Squamous cell carcinoma	166	11.7
Urothelial carcinoma	55	3.9
Melanoma	54	3.8
Neuroendocrine tumor	52	3.7
Tumor	49	3.5
Sarcoma	46	3.2
Germ cell tumor	40	2.8
Mesothelioma	12	0.9
Histologic grade^a
Well-moderately differentiated	418	37.6
Poorly differentiated/Undifferentiated	694	62.4

BCH, Beijing Cancer Hospital; FUSCC, Fudan University Shanghai Cancer Center; ZCH, Zhejiang Cancer Hospital
^aThe differentiation of 305 cases are not defined

ISSN: 1479-5876