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Table 2 Univariate and multivariate linear regression analysis for clinical variables associated with initial urinary TIMP-1 level

From: Derivation and validation of urinary TIMP-1 for the prediction of acute kidney injury and mortality in critically ill children

 

Univariate regressiona

Multivariate regressionb

 

B

SE

P value

B

SE

P value value

Age, months

0.100

0.073

0.17

N/A

  

Body weight, kg

0.139

0.161

0.39

N/A

  

Sex

− 0.116

0.100

0.25

N/A

  

PRISM III score

0.052

0.005

 < 0.001

0.031

0.006

 < 0.001

AKI stage

0.489

0.041

 < 0.001

0.377

0.049

 < 0.001

MV

0.494

0.103

 < 0.001

0.180

0.104

0.09

Sepsis

0.487

0.116

 < 0.001

0.277

0.102

0.007

MODS

1.099

0.159

 < 0.001

0.015

0.183

0.93

Shock/DIC

0.769

0.167

 < 0.001

− 0.325

0.175

0.06

Antibiotic

0.116

0.121

0.34

N/A

  

Inotrope

0.583

0.151

 < 0.001

− 0.251

0.151

0.10

Furosemide

0.411

0.106

 < 0.001

− 0.034

0.102

0.74

Steroid

− 0.239

0.095

0.01

− 0.110

0.081

0.17

Hemofiltration

1.021

0.182

 < 0.001

0.306

0.171

0.07

  1. AKI acute kidney injury, DIC disseminated intravascular coagulation, MODS multi-organ dysfunction syndrome, MV mechanical ventilation, N/A not applicable, PRISM III pediatric risk of mortality III. Continuous variables were log-transformed in the linear regression analyses
  2. aAll variables in Table 1 were analyzed in the univariate linear analysis
  3. bVariables with P < 0.05 were entered into the multivariate analysis after checking the multicollinearity by variance inflation factor and tolerance values