Table 1 Clinical characteristics of 10 SYSUCC patients with H3 G34-mutant diffuse hemispheric gliomas
| Â | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | Patient 8 | Patient 9 | Patient 10 |
|---|---|---|---|---|---|---|---|---|---|---|
Sex/age (years) | F/14 | F/18 | M/16 | F/20 | M/25 | F/23 | F/23 | M/13 | F/21 | M/21 |
Chef complaint | Headache, nausea and vomiting | Headache, nausea and vomiting | Weakness of right limbs | Generalized tonic clonic seizures | Generalized tonic clonic seizures | Headache, nausea and vomiting | Headache and weakness of left limbs | Dizziness and weakness of right foot | Generalized tonic clonic seizures | Weakness of left limbs |
Site of lesion | Left temporal lobe | Right frontal lobe | Left parietal lobe and corpus callosum | Bilateral frontal lobe and corpus callosum | Right frontal, temporal, insular lobe and basal ganglia | Right frontal lobe, corona radiata, basal ganglia and corpus callosum | Right frontal and insular lobe | Left frontal and parietal lobe | Left frontal lobe | Right frontal and parietal lobe |
Initial OP and adjuvant Tx | GTR + CCRT + TMZ#12 | GTR + CCRT + TMZ#2 | STR + CCRT | Biopsy + CCRT + TMZ#24 (continuously) | GTR + CCRT + TMZ#22 (continuously) | STR + CCRT | STR + CCRT | STR + CCRT + TMZ/DDP#4 + TMZ#6 | GTR + CCRT + TMZ#3 | GTR + Dianhydrodulcitol#12 |
2nd OP and adjuvant Tx | GTR + RT + TMZ#12 | NA | Conservative | NA | NA | Conservative | Conservative | Conservative | STR + TG02#1 | GTR |
H3F3A | G34R | G34R | G34V | G34R | G34R | G34R | G34R | G34R | G34R | G34R |
MGMT promoter | Methylated | Methylated | Un-methylated | Methylated | Methylated | Methylated | Methylated | Methylated | Methylated | Un-methylated |
IDH | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype |
TERT promoter | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype | Wildtype |
Morphology | GBM with primitive neuronal component | GBM | GBM | GBM | GBM | GBM | GBM | GBM | GBM | GBM with primitive neuronal component |
Current status | Death | Alive | Death | Alive | Alive | Death | Alive | Alive | Death | Alive |
OS (months) | 75 | 24 | 16 | 21 | 18 | 6 | 16 | 13 | 17 | 20 |