Fig. 7

Construction of overall survival risk model based on 36 ligands for TGF-beta, Hedgehog pathways and RTKs. A, B Screening of candidate ligands for risk model from 36 ligands that are differentially expressed and associated with overall survival. A Shows cross-validation of the lasso COX model to get the optimal lambda value (minimum). B Shows the lasso COX regression coefficients of 36 ligands at different lambda values. C The coefficient of the risk sore model by multivariate COX regression. D Risk score and expression of TGFB2 and VEGFB for each individual in TCGA cohort. E ROC curves of predicted survival at 1 year, 2 year and 5 year time point. F Kaplan–Meier plot of low and high risk group