Development and validation of a score to predict mortality in ICU patients with sepsis: a multicenter retrospective study

Table 2 Risk factors for predictive model for ICU mortality in the midwest development cohort (n = 4236)

Variable	β	OR (95%CI)^a	P-value	Point^b
Age, years
≥ 50 to < 60	0.7901	2.203 (1.294–3.899)	0.005	2
≥ 60 to < 75	1.0021	2.724 (1.641–4.724)	< 0.001	2.5
≥ 75	1.2261	3.407 (2.050–5.923)	< 0.001	3
Temperature < 37 °C	0.7332	2.081 (1.546–2.811)	< 0.001	2
Respiratory rate, breaths/min
≥ 30 to < 35	0.6111	1.842 (1.312–2.600)	< 0.001	1.5
≥ 35	0.5886	1.801 (1.292–2.526)	< 0.001	1.5
MAP ≤ 50, mmHg	0.8744	2.397 (1.673–3.481)	< 0.001	2
SpO2 < 90%	0.9508	2.587 (1.926–3.502)	< 0.001	2
Ventilation	1.2014	3.325 (2.665–4.156)	< 0.001	3
Albumin < 2, g/dL	0.6289	1.875 (1.343–2.639)	< 0.001	1.5
Bilirubin, mg/dL
≥ 0.8 to < 1.4	0.5366	1.710 (1.202–2.456)	0.003	1
≥ 1.4	0.7915	2.206 (1.559–3.158)	< 0.001	2
Lactate, mmol/L
≥ 2.5 to < 4.2	0.4558	1.577 (1.117–2.241)	0.010	1
≥ 4.2	0.9476	2.579 (1.869–3.595)	< 0.001	2
BUN, mg/dL
≥ 21 to < 33	0.4779	1.612 (1.117–2.349)	0.012	1
≥ 33 to < 52	0.4119	1.509 (1.049–2.192)	0.028	1
≥ 52	1.0401	2.829 (2.006–4.043)	< 0.001	2.5
Hepatic failure	1.0094	2.744 (1.468–4.993)	0.001	2.5
Metastatic cancer	0.5894	1.802 (1.051–2.997)	0.027	1
Total score				0–25

OR odds ratio
^aICU mortality odds ratio
^bAssignment of points to risk factors was based on a linear transformation of the corresponding β regression coefficient. The coefficient of each variable was divided by 0.4119 (the smallest absolute β value, corresponding to BUN ≥ 33 to < 52, mg/dL) and allocated an integer or an half integer score for each variable

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