Analysis of lncRNA-miRNA-mRNA expression pattern in heart tissue after total body radiation in a mouse model

Table 1 Biological roles of most significantly dose-responsive mRNAs

Gene symbol	Gene name	Biological process involvement	Previous reports related to radiation
Cdkn1a	Cyclin-dependent kinase inhibitor 1A	DNA damage-induced apoptosis; cell cycle arrest	[53, 54]
Gdf15	Growth differentiation factor 15	Heart-derived hormone; pathogenesis of atherosclerosis	[55, 56]
Ckap2	Cytoskeleton associated protein 2	Cell cycle arrest; essential for proper chromosome segregation	[57, 58]
Alas2	Aminolevulinic acid synthase 2, erthyroid	Hemoglobin metabolism pathway; cardiotoxicity	[59, 60]
Aplnr	Apelin receptor	Coordination of monocyte trafficking in hemeostatic and inflammatory states	[61, 62]
Cx3cr1	Chemokine (C-X3-C motif) receptor 1	Chemokine binding; cell adhesion	[63, 64]

Genes displayed correspond to the top three most significantly dose-responsive up- and down-regulated mRNAs shown in Fig. 1D. A short-list of biological process involvement and previous reports of involvement in the molecular response to radiation are shown

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