Fig. 2

Identification of differentially expressed m6A-related genes. a The density plot of the two datasets before normalization. b The density plot of the two datasets after normalization. c The heat map of 13 differentially expressed m6A methylation regulators. d Differentially expressed m6A-related genes between MS and non-MS patients using the Mann–Whitney U test. (ALKBH5: MS vs. non-MS = 5.587 ± 0.807 vs. 5.003 ± 0.820, p < 0.001; FTO: MS vs. non-MS = 7.976 ± 2.128 vs. 6.471 ± 2.043, p = 0.030; HNRNPC: MS vs. non-MS = 6.735 ± 0.441 vs. 6.288 ± 0.410, p < 0.001; KIAA1429: MS vs. non-MS = 5.535 ± 0.970 vs. 4.664 ± 0.822, p < 0.001; METTL14: MS vs. non-MS = 5.657 ± 0.648 vs. 5.016 ± 0.476, p < 0.001; METTL3: MS vs. non-MS = 6.299 ± 1.097 vs. 5.512 ± 0.600, p < 0.001; RBM15: MS vs. non-MS = 6.023 ± 0.490 vs. 5.305 ± 0.554, p < 0.001; WTAP: MS vs. non-MS = 6.292 ± 0.644 vs. 5.742 ± 0.607, p < 0.001; YTHDC1: MS vs. non-MS = 6.068 ± 0.841 vs. 5.206 ± 0.516, p < 0.001; YTHDC2: MS vs. non-MS = 5.914 ± 0.645 vs. 5.341 ± 0.556, p < 0.001; YTHDF1: MS vs. non-MS = 6.791 ± 1.337 vs. 6.114 ± 1.393, p = 0.004; YTHDF2: MS vs. non-MS = 6.716 ± 1.016 vs. 6.045 ± 1.098, p < 0.001; ZC3H13: MS vs. non-MS = 6.645 ± 1.255 vs. 5.572 ± 1.154, p < 0.001). The significant levels were set at p < 0.05 (*), < 0.01 (**), and < 0.001 (***). e Correlation analysis of the relationships between different m6A-related genes