A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

Moghadasi, Soudeh; Elveny, Marischa; Rahman, Heshu Sulaiman; Suksatan, Wanich; Jalil, Abduladheem Turki; Abdelbasset, Walid Kamal; Yumashev, Alexei Valerievich; Shariatzadeh, Siavash; Motavalli, Roza; Behzad, Farahnaz; Marofi, Faroogh; Hassanzadeh, Ali; Pathak, Yashwant; Jarahian, Mostafa

doi:10.1186/s12967-021-02980-6

Journal of Translational Medicine

Table 2 A brief overview of studies based on MSCs-exosomesin CNS-related disorders

From: A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

Condition	Sources	Main result	Refs.
MS	BM	Reduction in the mean clinical score of experimental autoimmune encephalomyelitis mice, attenuated demyelination, reduced neuroinflammation, and promotion of T regulatory cells frequencies by MSCs-exosomes	[159]
AD	BM	Boosted learning and memory competencies of APP/PS1 mice by amelioration of synaptic dysfunction and inhibition of inflammatory responses mediated via miR-21 by MSCs-exosomes	[112]
AD	BM	Improved learning and memory, suppressed reactive astrogliosis, diminished inflammation and microglial infiltration into the damaged hippocampus concomitant with supported blood–brain barrier integrity by MSCs-exosomesin a murine model	[160]
AD	WJ	Protection of hippocampal neurons from damage stimulated by amyloid-β oligomers (AβOs) resulting from enzymatically active catalase presented in MSCs-exosomesin vitro	[9]
AD	BM	A diminished level of NF-κB by miR-146a secreted from BM-MSCs in vitro	[113]
PD	BM	Recovery of dopaminergic neurons, and animal’s behavioral functions in the staircase test in rat models by MSCs-exosomes	[116]
MS ALS	BM	Modulation of the pro-inflammatory phenotype of activated N9 microglia cells in SOD1G93A mice models by inhibition of TNF- α and IL-1β expression by miR-467f and miR-466-enriched MSCs-exosomes	[161]
SCI	BM	Induction of neurogenesis and suppression cell apoptosis in SCI rat models by miR-126-modified MSCs-exosomes	[162]
SCI	BM	Hindrance of microglial polarization affecting TLR4/NF-κB/PI3K/AKT signaling cascades by-miR-216a-5p-enriched MSCs-exosomesin vitro	[163]
SCI	BM	Inducing the M2-type macrophages in SCI rat models by MSCs-exosomes	[164]
SCI	BM	Reduced lesion size and amended functional recovery and also cellular apoptosis and inflammation in the injured spinal cord in murine models by MSCs-exosomes	[165]
SCI	BM	Suppression of the migration of pericytes, improvement of the integrity of the blood-spinal cord barrier via NF-κB p65 signaling in pericytes, attenuated brain cell death, reinforced neuronal survival and regeneration and boosted motor function by MSCs-exosomes
SCI	BM	Inhibition of the apoptosis of neuron cells by inhibition of the expression of PTEN in a rat model by miR-21/miR-19b- enriched MSCs-exosomes	[166]

Micro RNA (miR), Bone marrow (BM), Wharton’s jelly (WJ), Multiple sclerosis (MS), Alzheimer’s diseases (AD), Parkinson’s diseases (PD), Spinal cord injury (SCI), Amyotrophic lateral sclerosis (ALS), Amyloid precursor protein (APP)/Presenilin-1 (PS1), Nuclear factor kappa-light-chain-enhancer of activated B cells, (NF-κB), Tumor necrosis factor α (TNF-α), Phosphatase and tensin homolog (PTEN)

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ISSN: 1479-5876

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