Fig. 9

Chemical structures of the three compounds identified by the connectivity map (CMap) analysis and the effect of these three compounds on GC cell proliferation and hubgenes expressions. A–C Chemical structures of the three compounds: A Vorinostat, B Astemizole, and C Trichostatin A. D, F, H GC cells were treated with increasing concentrations of D Vorinostat, F Astemizole, and H Trichostatin A, and GC cell proliferations were measured by CCK-8 assays. E, G, I GC cells were treated with E Vorinostat, G Astemizole, and I Trichostatin A, and the mRNA levels of 15 hubgenes were measured by qRT-PCR analysis