Fig. 4
From: Lipoprotein glomerulopathy induced by ApoE Kyoto mutation in ApoE-deficient mice
Typical renal pathologic lesions of lipoprotein glomerulopathy in the murine model. Panel a shows a glomerulus with accumulated lipoprotein thrombi in the dilated lumina of the glomerular capillaries (Toluidine blue staining, ×400), * show the lipoprotein thrombi accumulated area. Panel b shows ApoE primarily in the capillary lumina on immunofluorescence staining (frozen section, ×400). Panel c shows an obvious Oil-red O-positive area in the glomerulus (×400). Panel d shows numerous lipid granules deposited in the dilated capillary lumina of the glomeruli under electron microscope (×6000)