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Table 1 Demographic, clinical characteristics and FCGRIIB rs1050501 genotypes distribution of subjects enrolled in the study

From: Relation between FCGRIIB rs1050501 and HSV-1 specific IgG antibodies in Alzheimer’s disease

 

AD

MCI

Healthy controls

 N.

225

93

201

 Gender (M:F)

81:144

49:44

80:121

 Age, years

76.8 ± 6.4

75.0 ± 6.4

74.8 ± 10.3

 MMSE

18.7 ± 5.5*

24.8 ± 2.9

 APOE ε-4 carriers (%)

52.0#,°

39.5#

17.7

 HSV-1 IgG (AI)a

8.9; 7.1–10.1**

8.8; 6.7–11.1***

7.4 6.0–8.5

 HSV-1 Avidity index (%)a

87.9; 79.8–95.0

91.4; 85.7–97.6

90.1; 81.3–95.6

 FCGRIIB rs1050501 genotypes (%)

  TT

78.7

75.3

77.1

  CT

19.1

22.6

20.4

  CC

2.2

2.1

2.5

  1. Data are reported as mean ± standard deviation or as median; Interquartile range
  2. AD Alzheimer’s disease, MCI Mild Cognitive Impairment, M male, F female, MMSE mini mental state evaluation, APOE Apolipoprotein E, AI antibody index
  3. *p < 0.0001 compared to MCI
  4. #p < 0.0001 compared to HC
  5. °p = 0.046 compared to MCI
  6. **p = 0.001 compared to HC
  7. ***p = 0.0077 compared to HC
  8. aperformed on a subgroup of 69 AD 52 MCI and 49 HC