Fig. 2

Correlation between the densities of LAG-3, FGL1, PD-L1 and CD8⁺ T cells and quantitative assessment of LAG-3⁺cells and CD8⁺ T cells according to FGL1 or PD-L1 status on TC and IC in HCC. Associations between the densities of LAG-3, FGL1, PD-L1 and CD8 in HCC by Spearman correlation analysis (a–f). The densities of LAG-3⁺cells were higher but that of CD8⁺ T cells were lower in FGL1 TC⁺ and FGL1 IC⁺ than in FGL1 TC⁻ and FGL1 IC^– respectively (g–j). Both the densities of LAG-3⁺cells (k, l) and CD8⁺ T cells (m, n) were greater in patients with PD-L1 TC⁺ and PD-L1 IC⁺ than in PD-L1 TC⁻ and PD-L1 IC⁻, respectively. P values were determined by the Wilcoxon Rank-Sum test. TC tumor cells, IC immune cells