Simultaneous quantification of natural and inducible regulatory T-cell subsets during interferon-β therapy of multiple sclerosis patients

Table 1 Multivariable regression analysis of predicting factors affecting IL-10 mRNA levels

	Effect on log₂ IL-10	95% confidence interval	p*	Effect on IL-10	% of change**	95% confidence interval
log₂ CD49b in:
Unstimulated	0.476	0.157: 0.796	0.003	1.39	+ 39	1.115: 1.736
Stimulated	1.068	0.769: 1.367	0.000	2.1	+ 110	1.704: 2.580
log₂ Cyt-1 in:
Unstimulated	− 0.097	− 0.795: 0.601	0.785	0.93	− 7	0.576: 1.517
Stimulated	− 1.961	− 2.562: − 1.360	0.000	0.26	− 84	0.169: 0.390
log₂ Cyt-2 in:
Unstimulated	0.067	− 0.432: 0.565	0.793	1.05	+ 5	0.741: 1.479
Stimulated	0.558	0.121: 0.995	0.012	1.47	+ 47	1.088: 1.992
Stimulated vs unstimulated at:
T0	2.275	1.457: 3.093	0.000	4.84	+ 384	2.746: 8.534
T12	2.107	1.254: 2.960	0.000	4.31	+ 331	2.384: 7.782
T24	1.822	0.976: 2.667	0.000	3.53	+ 253	1.967: 6.352

*Calculated by exponentiating the coefficients reported in “effect on log₂ IL-10 column”
**Representing the % of change in IL-10 mRNA levels per each hypothetical doubling of the respective predictor level

ISSN: 1479-5876