HR (95% CI) | |
---|---|
Sex | |
Male vs female | 0.92 (0.58–1.46) p = 0.73 |
Age | |
> 62 vs < 62 | 0.70 (0.44–1.12) p = 0.13 |
BRAF | |
mut vs wt | 1.06 (0.66–1.70) p = 0.81 |
LDH | |
High vs normal | 1.62 (0.86–3.04) p = 0.13 |
Very high vs normal | 4.64 (2.52–8.54) p < 0.0001 |
Brain metastasis | |
Yes vs no | 1.92 (1.18–3.11) p = 0.008 |
Previous lines of treatment | |
2 vs 1 | 1.12 (0.62–2.02) p = 0.69 |
≥ 3 vs 1 | 1.38 (0.75–2.54) p = 0.30 |
Metastatic site | |
Lung vs soft tissue | 0.76 (0.30–1.87) p = 0.54 |
Visceral vs soft tissue | 1.85 (0.93–3.65) p = 0.08 |
Absolute lymphocyte count | 0.87 (0.60–1.25) p = 0.45 |
Relative lymphocyte count (≥ 20 vs < 20) | 0.96 (0.93–0.98) p = 0.001 |
Relative monocyte count | 0.94 (0.82–1.06) p = 0.32 |
Relative eosinophil count (≥ 1.5 vs < 1.5) | 0.75 (0.62–0.92) p = 0.006 |
Absolute neutrophil count (≥ 8 vs < 8) | 1.11 (1.04–1.17) p = 0.001 |
Relative neutrophil count (≥ 70 vs < 70) | 1.04 (1.01–1.06) p = 0.001 |
NLR | 1.04 (1.02–1.06) p < 0.0001 |
dNLR | 1.09 (1.04–1.14) p < 0.0001 |
Tot CD8+ cells | |
≥ 25.1 vs < 25.1 | 1.37 (0.86–2.18) p = 0.18 |
CD8+CD73+ cells (≥ 5.8 vs < 5.8) | 1.55 (0.97–2.48) p = 0.07 |
CD8+PD-1+ cells (≥ 9.8 vs < 9.8) | 1.86 (1.17–2.98) p = 0.009 |
CD8+PD-1+CD73+ cells (≥ 2.3 vs < 2.3) | 2.25 (1.39–3.63) p = 0.001 |