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Table 2 Univariate and multivariate analyses for survival of squamous cell carcinoma patients

From: Prognostic significance of peripheral CD8+CD28+ and CD8+CD28− T cells in advanced non-small cell lung cancer patients treated with chemo(radio)therapy

Variables

Overall survival

Progression-free survival

HR (95% CI)

P

HR (95% CI)

P

A (univariate)

 Gender

  Male

1.50 (0.56–3.96)

0.414

0.97 (0.42–2.25)

0.954

  Female

1

 

1

 

 Age (years)

  ≥ 60

0.47 (0.21–1.05)

0.069

0.49 (0.23–1.04)

0.065

  < 60

1

 

1

 

 Smoking status

  Ever smokers

1.08 (0.46–2.56)

0.852

0.81 (0.37–1.73)

0.581

  Never smokers

1

 

1

 

 cStage

  IV

1.22 (0.58–2.56)

0.597

1.15 (0.58–2.27)

0.681

  III

1

 

1

 

 Tumor differentiation

  Poor

1.30 (0.58–2.91)

0.52

1.29 (0.60–2.75)

0.512

  Well/moderate

1

 

1

 

 Performance status

  1–2

1.72 (0.72–4.06)

0.215

1.30 (0.63–2.68)

0.471

  0

1

 

1

 

B

1.29 (0.91–2.03)

0.328

1.17 (0.96–1.82)

0.532

NK

0.97 (0.57–1.82)

0.165

0.92 (0.62–1.56)

0.181

NKT

1.19 (0.73–1.65)

0.720

1.21 (0.86–1.76)

0.824

γδT

0.65 (0.35–1.36)

0.611

0.78 (0.43–1.44)

0.955

CD8+CD28+

1.01 (0.94–1.10)

0.749

0.99 (0.93–1.07)

0.902

CD8+CD28−

2.01 (1.16–4.05)

0.039

2.12 (1.07–4.36)

0.023

CD28+/CD28−

0.96 (0.68–1.37)

0.863

0.87 (0.61–1.22)

0.414

CD4+CD25hi

1.17 (0.68–2.04)

0.570

1.28 (0.78–2.10)

0.331

B (multivariate)

 Age (years)

0.47 (0.21–1.05)

0.064

0.48 (0.22–1.02)

0.057

 CD8+CD28−

1.41 (1.17–3.06)

0.035

2.01 (1.06–3.85)

0.029

  1. P-values for multivariate analyses are adjusted. The HR and 95% CI were reported for 1 SD increase for immune cells