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Table 2 Metabolites differentiating OIS from OIR + T2DM

From: Metabolic signature of obesity-associated insulin resistance and type 2 diabetes

Metabolites

Sub pathway

Super pathway

Fold change

Std. error

p value

1,5-Anhydroglucitol (1,5-Ag)

Glycolysis gluconeogenesis and pyruvate metabolism

Carbohydrate

− 0.92

0.4

0.041

12-Dilinoleoyl-Gpc (18:2/18:2)

Phosphatidylcholine (PC)

Lipid

0.47

0.2

0.037

12-Dilinoleoyl-Gpe (18:2/18:2)*

Phosphatidylethanolamine (PE)

Lipid

1.23

0.51

0.037

1-Methylhistamine

Histidine metabolism

Amino Acid

1.16

0.38

0.007

1-Ribosyl-Imidazoleacetate*

Histidine metabolism

Amino Acid

0.85

0.35

0.03

26-Dihydroxybenzoic Acid

Drug—topical agents

Xenobiotics

1.18

0.42

0.011

3-Amino-2-Piperidone

Urea cycle; arginine and Proline metabolism

Amino Acid

− 0.99

0.37

0.016

5-Methylthioadenosine

Polyamine metabolism

Amino Acid

1.18

0.38

0.006

Alpha-hydroxyisovalerate

Leucine isoleucine and valine metabolism

Amino Acid

0.7

0.27

0.023

Arachidonoylcholine

Fatty acid metabolism (acyl choline)

Lipid

− 1.05

0.41

0.021

Choline

Phospholipid metabolism

Lipid

− 0.46

0.17

0.013

Cortisol

Corticosteroids

Lipid

0.87

0.31

0.012

Docosatrienoate (22:3N3)

Long chain polyunsaturated fatty acid (n3 and n6)

Lipid

0.64

0.25

0.024

Formiminoglutamate

Histidine metabolism

Amino Acid

1.15

0.52

0.05

Gamma-tocopherol/beta-tocopherol

Tocopherol metabolism

Cofactors and Vitamins

1.38

0.55

0.024

Glucose

Glycolysis gluconeogenesis and pyruvate metabolism

Carbohydrate

0.3

0.12

0.025

Glycerol 3-phosphate

Glycerolipid metabolism

Lipid

− 0.93

0.38

0.029

Glycerophosphoethanolamine

Phospholipid metabolism

Lipid

− 1.24

0.47

0.019

Glycerophosphorylcholine (GPC)

Phospholipid metabolism

Lipid

− 1.85

0.77

0.032

HWESASXX*

Tyrosine metabolism

Amino Acid

− 1.44

0.59

0.029

Methionine sulfone

Drug—metabolic

Xenobiotics

0.89

0.34

0.018

Methylphosphate

Benzoate Metabolism

Xenobiotics

− 1.55

0.48

0.006

N-Formylanthranilic Acid

Fatty acid metabolism (acyl carnitine monounsaturated)

Lipid

0.9

0.4

0.044

N-Stearoyl-Sphinganine (D18:0/18:0)*

Endocannabinoid

Lipid

0.84

0.31

0.015

N-Stearoyl-Sphingosine (D18:1/18:0)*

Ceramides

Lipid

0.44

0.2

0.05

Pipecolate

Fatty acid dicarboxylate

Lipid

0.92

0.32

0.011

Ribitol

Vitamin A metabolism

Cofactors and vitamins

0.33

0.14

0.044

  1. Italicized rows represent metabolites that belong to the significantly enriched phospholipids pathway. Linear regression was performed to identify significant metabolites differentiating OIS from OIR and T2DM using the R statistical package after correcting for age, gender, BMI and principle components (PC1 and PC2). A p-value significance level of 0.05 was used. Asterisks (*) on IDs of some metabolites indicate that they have not been officially confirmed based on a standard, but their identities are known with confidence [23]
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Journal of Translational Medicine

ISSN: 1479-5876

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