Fig. 6From: Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonistsB1 and B2 receptor antagonists reduce mechanical (a), thermal (b) sensitivities and subjective pain (c) on the fractured tibia side in wild-type (WT) mice. Experiments were conducted as described in Fig. 1. At time 0, the B2 receptor antagonist Icatibant (HOE 140) was given as a single subcutaneous injection (250 µg/kg). B1 receptor antagonists were given either as gavage using SSR240612 (10 mg/kg body weight) or as a single subcutaneous injection of R954 (10 mg/kg body weight). Behaviors were recorded for 8 h and then once the subsequent day 24 h after drug administration. Each bar represents mean ± SEM of 6 mice per group. B: baseline. Data were subjected to Friedman’s test followed by Wilcoxon’ signed rank test. *, # and €P < 0.05 compared with saline-treated WT miceBack to article page