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Table 4 Stepwise regression analysis of adipokines and echocardiographic heart parameters

From: Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern

 

β

p

Systolic heart function

 EF

  Apelin SAT mRNA

− 0.29 ± 0.13

0.036

  TNF-α EAT mRNA

− 0.36 ± 0.13

0.010

  IL-6 SAT protein

0.38 ± 0.16

0.025

  Leptin SAT protein

0.37 ± 0.16

0.033

 TAPSE

  IL-6 plasma

− 0.34 ± 0.14

0.015

Diastolic heart function

 E/A

  Apelin plasma

0.40 ± 0.12

0.001

  Resistin plasma

− 0.30 ± 0.12

0.017

  Resistin SAT mRNA

− 0.36 ± 0.12

0.005

  Leptin plasma

− 0.28 ± 0.13

0.033

 DT

  Resistin plasma

0.38 ± 0.13

0.005

  Adiponectin plasma

0.36 ± 0.13

0.007

  Adiponectin SAT mRNA

0.31 ± 0.13

0.025

  Adiponectin SAT protein

0.52 ± 0.15

0.002

  Apelin SAT mRNA

0.34 ± 0.13

0.012

 E′

  IL-6 plasma

− 0.28 ± 0.13

0.030

 A′

  Leptin plasma

0.34 ± 0.16

0.041

  Leptin EAT protein

0.49 ± 0.15

0.003

 E′/A′

  IL-6 plasma

− 0.34 ± 0.13

0.014

  IL-6 EAT protein

− 0.37 ± 0.17

0.033

 DT′

  Leptin EAT mRNA

0.44 ± 0.13

0.002

  Resistin SAT mRNA

0.35 ± 0.13

0.008

Heart structure

 EATt

  Apelin SAT mRNA

0.35 ± 0.14

0.014

 PWTd

  Visfatin plasma

0.46 ± 0.13

0.001

  Adiponectin plasma

− 0.37 ± 0.13

0.005

  Leptin EAT protein

− 0.38 ± 0.16

0.021

 RVdD

  Resistin plasma

0.39 ± 0.12

0.002

  TNF-α SAT mRNA

0.27 ± 0.13

0.036

 LA

  Visfatin EAT protein

− 0.38 ± 0.15

0.017

 IVSD

  Leptin EAT mRNA

0.28 ± 0.13

0.041

 LVM

  TNF-α SAT mRNA

0.35 ± 0.13

0.011

  1. Stepwise regression analysis was performed on adipokines and parameters of heart function and heart structure; patient’s BMI and age were included in the model
  2. EF ejection fraction, TAPSE tricuspid annular plane systolic excursion, E/A the ratio of peak velocity blood flow in early diastole to peak velocity flow in late diastole, DT deceleration time of mitral inflow velocity, E′ peak mitral annulus velocity in early diastole, A′ peak mitral annulus velocity in late diastole, DT′ deceleration time of the mitral annulus measured in tissue Doppler, EATt epicardial adipose tissue thickness, PWTd posterior wall thickness at end-diastole, RVdD right ventricle diameter in diastole, LA left atrium diameter, IVSD interventricular septum thickness, LVM left ventricular mass, β standardized regression coefficient
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Journal of Translational Medicine

ISSN: 1479-5876

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