Fig. 8From: Diabetogenic effect of pravastatin is associated with insulin resistance and myotoxicity in hypercholesterolemic miceProposed model of the diabetogenic effects of pravastatin. Oxidative stress induced by long-term treatment with pravastatin causes a reduction in the phosphorylation of Akt, which is permissive for proteolysis and apoptosis. Alternatively, oxidative stress may directly activate the apoptosis cell programmeBack to article page