Fig. 2
Long-term pravastatin treatment impairs insulin sensitivity in LDLr−/− mice. Insulin tolerance tests (ITTs) were performed after 3 months (a, b), 6 months (c, d) and 10 months (e, f) of treatment. Blood glucose concentrations (%) (a, c and e), and disappearance rates (Kitt)(b, d, and f) are shown. Mean ± SE. *p < 0.05 as determined by Student’s t-test between untreated (control) and pravastatin-treated mice (n = 4–6)