Fig. 4

IDH2 inhibition decreased exocrine function and the expression of several key genes. a The levels of growth hormone were 78 ± 15.3 and 72.3 ± 13.7 mIU/m and the levels of IGF-l 74.5 ± 12.7 and 63.4 ± 15.3 mIU/m after shRNA C and D plasmid blockage in GH3 cell lines. a The mRNA of E-cadherin in shRNA C and D plasmid knockdown group was 3.18 and 4.28 folds of that in control group, and N-cadherin 0.47 and 0.24 folds, and MMP2 0.35 and 0.22 folds. c The mRNA of IL-6 in shRNA C and D plasmid knockdown group was 0.65 and 0.26 folds of that in control group, and STAT3 0.34 and 0.24 folds, and STAT5 0.41 and 0.23 folds. All assays were performed in triplicate. **Compared to control, p < 0.01. *Compared to control, p < 0.05