Journal of Translational Medicine

Table 1 Expression pattern of GJB2 and TMPRSS3 genes

From: Overinterpretation of high throughput sequencing data in medical genetics: first evidence against TMPRSS3/GJB2 digenic inheritance of hearing loss

Inner ear structure	GJB2 expression		TMPRSS3 expression
Inner ear structure	Rodents [22]	Human [9]	Rodents [23, 24]	Human [10]
Inner hair cells	−	−	+	+
Outer hair cells	−	−	±	+
Interdental cells	+	N/A	+	N/A
Spiral limbus	+	N/A	−	N/A
Inner sulcus cells	+	N/A	+	N/A
Inner pillar cells	+	−	−	+
Outer pillar cells	+	+	−	+
Deiter’s cells	+	+	+	+
Hensen cells	+	+	+	N/A
Claudius cells	+	+	+	N/A
External sulcus cells	+	N/A	+	N/A
Stria vascularis	+	+	+	±
Spiral ligament	+	+	−	N/A
Spiral ganglion	−	+	+	±

−, no expression detected; +, detected expression; ±, inconsistent expression data; N/A, no data available

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ISSN: 1479-5876

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