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Table 6 Representative analysis of main cell populations in patients

From: First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells

Patient ID

TCD4

TCD8

NK

B

1 w

1 m

B

1 w

1 m

B

1 w

1 m

3

24.8

20.0

27.4

20.1

20.1

27.2

8.9

–

10.4

5

8.0

3.4

5.6

3.9

2.6

2.6

19.9

13.5

23.4

8

–

12.9

14.1

–

8.5

10.2

–

3.1

6.6

10

13.4

13.6

9.6

8.5

18.7

17.5

7.3

–

–

14

30.8

35.7

36.9

32.3

31.0

28.6

5.0

3.7

3.1

15

12.6

9.2

79.9

7.8

8.0

7.3

16.3

12.6

13.9

18

12.9

11.6

13.6

4.1

8.8

5.7

11.1

3.6

10.3

21

13.8

17.9

14.6

3.4

4.1

4.0

17.6

15.9

21.7

24

49.0

32.3

51.0

6.0

3.7

6.1

6.9

3.3

5.7

26

15.0

16.6

14.1

15.9

16.3

13.7

20.9

21.0

16.1

27

22.4

19.1

8.9

9.3

11.5

3.8

4.8

10.3

6.4

28

48.2

36.4

41.9

5.2

6.5

5.6

–

8.6

6.5

29

0.4

0.6

0.6

1.2

2.1

1.7

1.6

2.2

1.7

30

22.6

22.9

23.7

8.6

7.1

14.3

6.3

6.0

6.4

Patient ID

MDSC

Tem

Tcm

B

1 w

1 m

B

1 w

1 m

B

1 w

1 m

3

0.6

0.6

–

1.8

2.1

2.9

1.5

1.6

2.3

5

1.8

2.3

2.3

0.5

0.3

0.5

0.5

0.3

0.3

8

–

2.7

2.1

–

3.6

3.7

–

0.3

0.3

10

1.6

–

2.0

0.5

–

2.3

0.2

–

0.4

14

0.5

0.8

0.3

3.8

3.5

3.1

19.8

17.1

14.8

15

1.1

2.0

1.2

2.1

2.7

2.3

0.5

0.6

0.8

18

2.0

1.9

3.5

0.9

3.2

1.8

0.0

0.1

0.0

21

1.7

2.4

1.7

1.2

1.3

1.4

0.0

0.1

0.1

24

0.3

0.9

0.9

0.5

0.4

0.4

1.2

0.7

1.1

26

0.5

0.7

1.1

2.3

2.6

2.2

0.1

0.2

0.2

27

1.2

0.6

0.4

3.4

3.3

1.2

0.1

0.1

0.1

28

0.5

0.7

0.4

3.3

4.2

4.3

0.2

0.2

0.2

29

9.0

5.1

6.0

0.1

0.2

0.2

0.1

0.2

0.1

30

0.3

0.2

0.2

3.0

2.0

4.3

0.5

0.5

0.5

  1. Patients’ blood samples were analyzed by flow cytometry at different time-points after treatment: B: baseline; 1 w: 1 week post treatment; 1 m: 1 month post treatment. Data represent percent of total PBMC. Cell populations: TCD4 (CD3+ CD4 +), TCD8 (CD3+ CD8 +), NK (CD3−CD56 +), MDSC (Lin-DR-CD3 + CD116+), Tem (CD3+ CD8+ CD45RA-CD197−), Tcm (CD3+ CD8+ CD45RA−CD197+)