Table 4 DNMT3A R882 mutations and clinical factors in Cox regression analysis for AML prognosis
Variables in the model | Overall survival (n = 870) | Disease-free survival (n = 688) | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
DNMT3A R882 mutations | 1.725 (1.221–2.437) | 0.002 | 1.694 (1.114–2.577) | 0.014 |
Age, years | 1.018 (1.010–1.026) | 7.47 × 10 −6 | 1.005 (0.997–1.014) | 0.229 |
WBC count, ×109/L | 1.002 (1.001–1.004) | 0.007 | 1.002 (1.000–1.004) | 0.051 |
Platelets count, ×109/L | 0.997 (0.995–0.999) | 0.011 | 0.999 (0.997–1.001) | 0.159 |
Risk stratifications |  | 6.80 × 10 −22 |  | 9.13 × 10 −7 |
 Low vs. intermediate | 0.681 (0.512–0.907) | 0.009 | 0.693 (0.522–0.920) | 0.011 |
 High vs. intermediate | 2.729 (2.146–3.469) | 2.53 × 10 −16 | 1.794 (1.323–2.433) | 1.68 × 10 −4 |