Key metabolic parameters change significantly in early breast cancer survivors: an explorative PILOT study

Table 2 Metabolic profile and females sex hormones of premenopausal patients at baseline (T0) compared to premenopausal healthy controls

	Premenopausal controls (n = 15)	Premenopausal BC patients (T0) (n = 13)	P-value^c
BMI (kg/m²)^b	*24.4* [22.4; 26.0]	*25.7* [22.6; 29.0]	0.4
Waist (cm)^a	*84.6* ± 9.93	*84.8* ± 6.5^e	0.9
Body fat (%)^a	*32.3* ± 5.70	*34.1* ± 7.0	0.4
Lean body mass (kg)^a	*44.2* ± 4.88	*44.8* ± 4.93	0.6
Bone mineral density (g/cm²)	*1.20* ± 0.08	*1.17* ± 0.05	0.2
Total cholesterol (mmol/L)	*5.03* ± 0.94	*5.22* ± 0.94	0.6
LDL (mmol/L)^a	*3.06* ± 0.86	*2.93* ± 0.96	0.7
HDL (mmol/L)^a	*1.52* ± 0.39	*1.78* ± 0.47	0.1
Triglyceride (mmol/L)^b	*0.8* [0.7; 1.36]	*1.10* [0.88; 1.3]	0.2
Glucose (mmol/L)^a	*5.2* ± 0.38	*5.5* ± 0.47	0.1
Insulin (pmol/L)^b	*27.5* [21.8; 34.6]	*36.5* [25.8; 51.6]	0.1
HbA1c (mmol/mol)^a	*35.1* ± 3.13	*35.3* ± 4.15	0.9
Systolic blood pressure (mmHg)	*115* ± 10.6	*112* ± 11.8	0.5
Diastolic blood pressure (mmHg)	*72.3* ± 7.12	*71.0* ± 8.47	0.7
Hs-CRP (mg/L)^b	*0.63* [0.6; 1.2]	*1.04* [0.68; 2.45]	0.1
CD163 (mg/L)	*1.54* [1.40; 2.04]	*1.66* [1.27; 2.10]	0.9
CD206 (mg/L)	*0.20* [0.15; 0.24]	*0.21* [0.17; 0.25]	0.6
MetS^f	*2 (13%)*	*0 (0%)*	0.2 ^d
FSH (IU/L)	*8.4* [5.82; 31.6]	*3.9* [3.0; 22.1]	0.03*
LH (IU/L)	*9.9* [7.39; 25.5]	*4.7* [3.0; 36.1]	0.1
Estradiol (pmol/L)	*338* [119; 701]	*471* [124; 752]	0.6

The italic values reflect P-values, and the bolditalic values reflects means/medians
BMI body mass index, LDL low-density lipoprotein, HDL high-density lipoprotein, HbA1c hemoglobin A1c, Hs-CRP high sensitivity C-reactive protein, MetS metabolic syndrome, FSH follicle-stimulating hormone, LH luteinizing hormone
* Statistical significant
^aMean
^bMedian
^cTwo sample T-test for means and Wilcoxon rank sum test for medians
^dPearson chi² test
^en = 12
^fAt least 3 of the following 5: HDL < 1.3, triglycerides ≥ 1.7, waistline > 88 cm, fasting glucose ≥ 6.1, blood pressure ≥ 130/85

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