Fig. 4

Frequency of myeloid-derived suppressor cells (MDSCs) in patients with CML receiving TKIs, either alone or in combination with IFN-α. a Gating strategy for the identification of granulocytic MDSCs (Gr-MDSCs: CD45⁺CD11b^brightCD33^dimCD15⁺Arg1⁺) and monocytic-like MDSCs (Mo-MDSCs: CD45⁺CD11b^brightCD33^brightCD15^negArg1^neg). The frequency of Gr-MDSCs (b), Mo-MDSCs (c) and the ratio of Gr-MDSCs to Mo-MDSCs (d) are shown in CML patients and in healthy controls. Results are summarized as the mean ± SEM. The p values in the figure reflect statistically significant differences among study groups