Fig. 2

MR-proANP levels are elevated in critically ill patients with sepsis and correlate with inflammatory markers a ICU patients with sepsis displayed significantly elevated MR-proANP levels compared to patients without sepsis. b Receiver operating characteristic (ROC) curve analyses comparing the diagnostic power in predicting sepsis of MR-proANP (black line, area under the curve (AUC) 0.656) with classical markers of inflammation and bacterial infection, C-reactive protein (CRP, grey line, AUC 0.847) and white blood cell count (leukocytes, dotted grey line, AUC 0.585). c–d MR-proANP correlates with experimental markers of inflammation in critical illness like soluble urokinase-type plasminogen activator receptor (suPAR, C) and N-terminal pro C-type natriuretic peptide (NT-proCNP, D). e At ICU admission, MR-proANP levels are significantly elevated in critically ill patients with high initial Acute Physiology and Chronic Health Evaluation (APACHE II) score (> 10) in comparison to patients with low APACHE-II scores (≤ 10). p-values (U-test or Spearman rank correlation) are given