Table 1 Macrophage subtypes involved in aortic remodeling and aneurysm
From: Diverse roles of macrophage polarization in aortic aneurysm: destruction and repair
Disease modle/objects | Pathway/key regulators | References |
|---|---|---|
Ang II-infused ApoE−/− mice | M2 macrophage accumulation in the aortic wall | Moore et al. [19] |
Human aneurysmal infrarenal aortic wall | M1 macrophage was predominant in the adventitia while the M2 macrophages in the intraluminal thrombus/stabilin 1 | Boytard et al. [20] |
Ang II-infused ApoE−/− mice | Notch1 | Hans et al. [21] |
Cerebral aneurysms | Macrophage M1/M2 imbalance and upregulation of mast cells | Hasan et al. [22] |
Patients with AA | IL-1β was differentially expressed in human plasma with in patients with AA | Batra. et al. [23] |
Patients with AA | NF-stimulated gene-6 (TSG-6) elevated in both the plasma and aortic wall of patients with AA | Wang et al. [24] |