Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study

Table 3 Univariate Cox analysis of factors in relation to all-cause mortality and cardiovascular events

	Unite increase	All-cause mortality (n = 77)		Fatal and non-fatal cardiovascular events (n = 57)
	Unite increase	HR (95%)	p value	HR (95%)	p value
Age	1 year	1.06 (1.04–1.08)	< 0.001	1.04 (1.02–1.07)	< 0.001
Male gender	–	0.94 (0.60–1.46)	0.8	0.88 (0.53–1.48)	0.6
Diabetes mellitus	–	2.39 (1.52–3.77)	< 0.001	2.29 (1.35–3.89)	0.002
Hypertension	–	4.75 (0.66–34.18)	0.1	3.52 (0.49–25.46)	0.2
Background AVD	–	4.94 (3.10–7.88)	< 0.001	4.59 (2.69–7.85)	< 0.001
Background VC	–	2.02 (1.25–3.26)	0.004	1.33 (0.73–2.41)	0.3
Ca × P	1 mg²/dL²	1.0 (0.98–1.01)	0.4	1.0 (0.98–1.01)	0.6
iPTH	1 pmol/L	1.0 (0.99–1.0)	0.4	0.99 (0.99–1)	0.2
hs-CRP	1 mg/L	1.02 (1.0–1.03)	0.03	1.01 (0.99–1.03)	0.2
Serum albumin	1 g/L	0.91 (0.86–0.95)	< 0.001	0.91 (0.89–0.97)	0.001
Hemoglobin	1 g/L	1.0 (0.98–1.01)	0.7	1.00 (0.99–1.02)	0.8
LDL cholesterol	1 mmol/L	1.19 (0.99–1.44)	0.06	1.31 (1.09–1.57)	0.004
LV mass index	1 g/m²	1.002 (0.99–1.01)	0.2	1.004 (1.0–1.008)	0.05
Log₁₀ Angpt-2	1 ng/mL	3.67 (1.43–9.45)	0.007	6.71 (2.15–20.88)	0.001
Residual renal function	1 mL/min	0.93 (0.83–1.04)	0.2	0.97 (0.86–1.10)	0.7

Calcium × phosphorus product in mg²/dL² to mmol²/L², × 0.0806
AVD atherosclerotic vascular disease, VC valvular calcification, Ca × P calcium × phosphorus product, iPTH intact parathyroid hormone, hs-CRP high sensitive C-reactive protein, LDL lower-density lipoprotein, LV left ventricular, Angpt-2 angiopoietin-2

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