Table 3 UGT1A1 polymorphisms and clinical variables of multivariate analysis for non-CR risk in AML
Variables in the model | Non-CR risk after two courses of induction | Non-CR risk after the first course of induction | ||
|---|---|---|---|---|
OR (95% CI) | P value | OR (95% CI) | P value | |
UGT1A1 *28/− or *6/− | 0.547 (0.375–0.797) | 0.002 | 0.622 (0.446–0.868) | 0.005 |
Risk stratification groups |  | 2.5 × 10−6 |  | 0.021 |
 Low vs intermediate | 0.457 (0.269–0.776) | 0.004 | 0.678 (0.455–1.011) | 0.056 |
 High vs intermediate | 2.045 (1.331–3.140) | 0.001 | 1.365 (0.880–2.116) | 0.164 |
WBC count, × 109/l | 1.004 (1.001–1.007) | 0.008 | 1.005 (1.001–1.008) | 0.011 |
Age, years | 1.014 (1.001–1.028) | 0.036 | 1.005 (0.993–1.017) | 0.448 |