Table 3 Pharmacokinetic parameters in human following single oral doses of MIV-711
Dose (mg) | Cmax (µmol/L) | AUC0–t (µmol/L × h) | AUCinf (µmol/L × h) | t½ (h) | t amax (h) | Cmax/dose | n |
|---|---|---|---|---|---|---|---|
20 | 0.033 (36) | 0.128 (36) | 0.158 (32) | 3.4 (13) | 1.0 (0.50–2.0) | 0.12 (26) | 7 |
100 | 0.293 (35) | 1.13 (38) | 1.17 (37) | 3.7 (15) | 1.0 (1.0–2.2) | 0.21 (23) | 7 |
200 | 0.756 (43) | 2.45 (36) | 2.51 (35) | 5.0 (16) | 1.0 (0.50–1.0) | 0.27 (36) | 7 |
400 | 1.18 (43) | 4.62 (33) | 4.75 (32) | 6.5 (44) | 1.0 (1.0–1.5) | 0.23 (37) | 7 |
600 | 1.39 (37) | 6.75 (30) | 6.89 (30) | 8.3 (34) | 1.0 (1.0–3.0) | 0.17 (38) | 7 |