Fig. 5
From: Comprehensive molecular biomarker identification in breast cancer brain metastases
The top canonical pathway is entitled, role of BRCA1 in DNA damage response. The pathway is based on the list of 370 differentially expressed probe sets and is displaying the expression values derived from the BCBM vs. BC comparison group (Additional file 1). Molecules that are comparably upregulated in BCBM include RAD51, DPF1, RFC4, E2F1, BRIP1, and BLM. The pathway was overlaid with the Molecule Activity Predictor to precalculate further molecular effects, as outlined in the prediction legend