Table 4 The number of genes targeted by the miRNAs in the altered pathways
From: Bovis Bacillus Calmette–Guerin (BCG) infection induces exosomal miRNA release by human macrophages
Pathways | Gene | p value |
|---|---|---|
Pathways in fatty acid metabolism | ||
Fatty acid biosynthesis | 2 | 0.000000000684 |
Fatty acid metabolism | 12 | 0.00000154 |
Fatty acid elongation | 7 | 0.000738 |
Steroid biosynthesis | 6 | 0.00631 |
2-Oxocarboxylic acid metabolism | 6 | 0.0165 |
Pathways in amino acids metabolism | ||
Phenylalanine, tyrosine and tryptophan biosynthesis | 4 | 0.000713 |
Valine, leucine and isoleucine degradation | 12 | 0.0310 |
Lysine degradation | 16 | 0.0421 |
Pathways of energy production and sugar metabolism | ||
Central carbon metabolism in cancer | 19 | 0.00435 |
2-Oxocarboxylic acid metabolism | 6 | 0.0165 |
Glycosaminoglycan biosynthesis—heparan sulfate/heparin | 9 | 0.0113 |
Proteoglycans | 49 | 0.0337 |
Pathways in infection | ||
Bacterial invasion of epithelial cells | 23 | 0.0310 |
Endocytosis | 51 | 0.0337 |
ECM-receptor interaction | 16 | 0.00153 |
Adheres junction | 21 | 0.00730 |
Inositol phosphate metabolism | 15 | 0.0201 |
Cell signaling pathways | ||
Phosphatidylinositol signaling system | 21 | 0.0489 |
TGF-beta signaling pathway | 18 | 0.0489 |
Pathways in bacterial digestion | ||
Proteasome | 3 | 0.0138 |
Ubiquitin mediated proteolysis | 7 | 0.00566 |