Fig. 4
From: FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model
FTY720 reduces tumor growth in MM syngeneic model without causing toxicity. a Suppression of viability of AB1 mouse cell line in vitro upon 48 h of treatment with indicated FTY720 doses. b–d Balb/c mice inoculated subcutaneously with AB1 mouse cells were treated with 10 mg/kg FTY720 or vehicle (n = 15 mice per group) on a 5/2 on/off schedule. Treatment was initiated once tumors reached a palpable size of 0.5 mm. Mice were weighted throughout the duration of the study to monitor for system toxicity b. Tumor volumes were measured every 3 days and growth curve was plotted c. Final tumor weights were also measured d