Fig. 3

Administration of the mRNA vaccine induces multiple genes of innate immunity in MIMIC®-PTE immune cell populations. Transcriptional response to the mRNA vaccine is compared with R848. The 86 genes shown were taken from the subset of genes designated as immune-related. The heat map represents normalized mean expression values depicted as log2 fold change relative to the respective buffer control. Transcripts were grouped by their immune function. Number of donors in each group = 6