Fig. 4

Heterologous Gag immunization induces high numbers of Env specific CD8+ T cells. Mice were analysed for respective CD4+ and CD8+ T cell responses at day 69 upon sacrifice and harvest of spleens for analysis. Frequency of IFN-γ positive CD8+ and CD4+ T cells against SIVmac239 Env. Shown are calculated total numbers of responding CD8+ T cell per spleen of individual mice. Horizontal lines depict the mean of the groups