Table 5 The p values (as a function) of affected inflammatory signaling pathways between PYS and HPG compared to Control
Signaling pathways (total number of genes) | PYS | HPG |
|---|---|---|
B cell development (35) | NS (−2) | 0.023 (−3) |
Complement (37) | NS (+2) | NS (+1) |
Cross talk between DCs and NK cells (89) | 0.0083 (+1, −4) | NS (−4) |
Granulocyte adhesion and diapedesis (177) | 1.32 × 10−6 (+11, −2) | 0.0014 (+7, −3) |
Agranulocyte adhesion and diapedesis (189) | 7.4 × 10−5 (+10, −1) | 0.0071 (+7, −2) |
ICOS/ICOSL signaling in Th cells (122) | NS (+2, −2) | 0.0063 (+3, −4) |
Antigen presentation pathway (37) | NS (−2) | NS (−1) |
Nur 77 signaling in T cells (59) | NS (+1, −1) | NS (−1) |
Acute phase response signaling (169) | 7.8 × 10−7 (+11, −2) | NS (+4) |
CD28 signaling in Th cells (131) | NS (+2, −2) | 0.0302 (+2, −4) |
IL-17A signaling in fibroblast (35) | 0.0126 (+1, −2) | NS (−1) |
Role of hypercytokinemia/hyperchemokinemia in the pathogenesis (43) | NS (+1) | NS (−1) |
IL-10 signaling (68) | NS (+2, −1) | NC |
Differential regulation of cytokine production in MΦ and Th cell (18) | NS (+1) | NC |
Inhibition of matrix metalloproteinase (39) | 0.0002 (+3, −2) | NC |
TREM1 signaling (75) | NS (+1, −1) | NC |
IL-6 signaling (127) | 0.0021 (+6, −1) | NS (+3, −1) |
Toll-like receptor signaling (74) | NS (+1, −1) | NC |
MIF-mediated glucocortical regulation (33) | NS (+1, −1) | NS (+2) |
MIF regulation of innate immunity (41) | 0.0195 (+2, −1) | NS (+2) |
HMGB1 signaling (133) | 0.0389 (+4, −1) | NS (+3) |