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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment

Fig. 6

Secretion of PDGF-AA (a), PDGF-BB/AB (b), and IL-6 (c) were quantified over time using a magnetic bead assay approach. Concentrations of PDGF-AA rose earlier and were significantly higher than PDGF-BB, -AB or IL-6 in the conditioned media of JHU-011 and -019 (p < 0.007). To determine if PDGF-AA mediated secretion of IL-6, JHU-011 and -019 cells were treated with 5 ng PGGF-AA and IL-6 secretion compared to unstimulated cells (d, e). Stimulation with PDGF-AA resulted in a significant increase in IL-6 secretion (p < 0.001). All experiments performed in duplicate for n = 2 observations

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Journal of Translational Medicine

ISSN: 1479-5876

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