| | Sensitivitya (%) | Specificitya (%) | Cohen’s κ coefficient$
|
|---|
Thresholds |
200 CD4 T cells/μl* | 96.7 | 100 | 0.98 |
350 CD4 T cells/μl** | 100 | 100 | 1.00 |
750 CD4 T cells/μl*** | 100 | 83.9 | 0.89 |
25 %CD4+*** | 95.5 | 100 | 0.95 |
- * 200 CD4 T cells/µl: threshold of immune-restauration under antiretroviral treatment and the threshold for therapeutic initiation according to the 2006-revised WHO recommendations [28]
- ** 350 CD4 T cells/µl: WHO threshold for antiretroviral treatment initiation in adults and children aged more than 5 years according to the 2010-revised WHO guidelines [29] and threshold for antiretroviral treatment initiation as a priority for adults, adolescents (10–19 years old) and children aged more than 5 years according to the 2015-revised WHO guidelines [6] and to the 2016-consolidated WHO guidelines [7]
- *** 750 CD4 T cells/µl and 25 %CD4+: absolute and percent CD4 T cell count 2010-revised WHO thresholds for antiretroviral treatment initiation in children aged between 24 and 59 months [29] and thresholds for antiretroviral treatment initiation as a priority for children aged more than 2 years and less than 5 years according to the 2015-revised WHO guidelines [6] and to the 2016-consolidated WHO guidelines [7]
-
$A 10% bilateral range (i.e., counts between 190 and 210 CD4 T cells/μl for the threshold at 200 CD4 T cells/μl; counts between 332 and 367 CD4 T cells/μl for the threshold at 350 CD4 T cells/μl; counts between 712 and 787 CD4 T cells/μl for the threshold at 750 CD4 T cells/μl; and counts 23.7 and 26.2 %CD4+ for the threshold at 25 %CD4+) was considered similar
-
aThe sensitivity and specificity of CD4 T cell counting by the Muse™ Auto CD4/CD4% system to identify patients having less than (or more than) 200 CD4 T cells/µl and 350 CD4 T cells/µl, were calculated on the 150 available CD4 T cell count measurements from infants, children, adolescents and adults
