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Table 1 Identification of quadruple wild-type GIST (qWT) Subset in 186 GIST

From: FGFR1 and NTRK3 actionable alterations in “Wild-Type” gastrointestinal stromal tumors

Category

Number of patientsa

Percent of patients (%)

KIT mutated

129

69

PDGFRA mutated

22

12

NF1 mutated

18

10

SDH [ABCD] mutated

14

8

BRAF mutated

7

4

[KNH] RAS mutated

4

qWT

12

SDH unknown

12

  1. aGenomic alterations are not mutually exclusive and are potentially germline (e.g., NF1 and SDH [ABCD]). Of the 162 non-WT GISTs, 32 tumors had one or more genomic alterations in KIT, PDGFRA, NF1, SDH [A-D], BRAF, and/or [KNH] RAS