Table 1 Clinicopathologic characteristics and histological analysis
From: Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants
Total (N = 52) | EML4 variants (N = 33) | Non-EML4 variants (N = 19) | P value | |
|---|---|---|---|---|
Clinicopathologic parameters | ||||
Age, median (range) | 52 (31–76) | 50 (31–76) | 55 (32–70) | 0.227 |
Women (%) | 29 (55.8) | 21 (63.6) | 8 (42.1) | 0.132 |
Smoking history (%) and pack-years | 0.904 | |||
Never smoker | 35 (67.3) | 23 (69.7) | 12 (63.2) | |
Ex-smoker, pack-years | 6 (11.5), 17.7 | 4 (12.1), 19.4 | 2 (10.5), 14.3 | |
Current smoker, pack-years | 11 (21.2), 23.1 | 6 (18.2), 19.6 | 5 (26.3), 27.4 | |
Pathologic stage | 0.546 | |||
IIIB | 3 (5.8) | 1 (3.0) | 2 (10.5) | |
IV | 49 (94.2) | 32 (97.0) | 17 (89.5) | |
Metastasis sites | ||||
Brain | 23 (44.2) | 14 (42.4) | 9 (47.4) | 0.730 |
M1a sites | 28 (53.8) | 22 (66.7)* | 6 (31.6) | 0.015 |
M1b sites | 35 (67.3) | 22 (66.7) | 13 (68.4) | 1.000 |
M1ab sites | 49 (94.2) | 32 (97.0) | 17 (89.5) | 0.546 |
Death | 19 (36.5) | 11 (33.3) | 8 (42.1) | 0.527 |
Histologic parameters | ||||
Presence of mucin | 10 (22.7) | 5 (17.2) | 5 (33.3) | 0.271 |
Intracellular, columnar cells | 4 (9.1) | 1 (3.4) | 3 (20.0) | 0.107 |
Intracellular, signet ring cells | 7 (15.9) | 4 (13.8) | 3 (20.0) | 0.675 |
Extracellular | 4 (9.1) | 1 (3.4) | 3 (20.0) | 0.107 |
Predominant pattern | 0.443 | |||
Acinar | 15 (38.5) | 8 (33.3) | 7 (46.7) | |
Solid | 18 (46.2) | 11 (45.8) | 7 (46.7) | |
Cribriform | 4 (10.3) | 4 (16.7) | 0 (0.0) | |
Micropapillary | 2 (5.1) | 1 (4.2) | 1 (6.7) | |
Cribriform pattern | 10 (22.7) | 7 (24.1) | 3 (20.0) | 1.000 |
Solid signet rings | 25 (56.8) | 17 (58.6) | 8 (53.3) | 1.000 |
Prominent nucleoli | 17 (38.7) | 14 (48.2) | 3 (20.0) | 0.136 |
Psammomatous calcification | 6 (13.6) | 4 (13.8) | 2 (13.3) | 1.000 |