Fig. 5From: In-vitro influence of mycophenolate mofetil (MMF) and Ciclosporin A (CsA) on cytokine induced killer (CIK) cell immunotherapyInfluence of MPA exposure on receptors involved in CIK cell mediated killing and cell migration. FasL, TRAIL, DNAM, CD11a, CXCR3 and CCR5 were analyzed following short- (24 h), intermediate- (3 days) and long-term (7 days) MPA treatment and all receptors were compared to their individual controls (only 24 h control is displayed). a–c Analyzing receptors involved in CIK cell mediated killing, we observed a stable expression of FasL, TRAIL and DNAM upon short- and intermediate-term MPA treatment. A reduced expression of FasL and TRAIL on T cells and an increased expression of DNAM following long-term MPA exposure was determined (p < 0.05). d–f With regard to CIK cell migration, no alteration in the expression of CD11a, CXCR3 and CCR5 upon short-term MPA exposure was observed. CD11a was downregulated on T cells and upregulated on NK-like T and NK cells following intermediate- and long-term MPA treatment (p < 0.05 and p < 0.01). CXCR3 was downregulated on T cells upon long-term MPA incubation (p < 0.05), whereas CCR5 was expressed to a higher extend on NK-like T cells. n = 5 independent experimentsBack to article page