Fig. 3

Knee range of motion along the study. The median values expressed in degrees of the goniometric measurements of the knee flexion (top) and extension (bottom) ranges of motion before administration of treatments and 3, 6 and 12 months afterwards are presented. *p < 0.05; **p < 0.01 with respect to the baseline value of the high-dose group. ^#p < 0.05 with respect to the baseline valued of the low-dose group