Fig. 1

Semi-chronic arthritis is more severe in ApoE^−/− mice compared to C57BL/6 mice. C57BL/6 (control) and ApoE^−/− mice (n = 4–5 mice/group) were fed chow until 8 weeks of age, at which time they were fed a Western diet for an additional 2–4 months. Animals received serial injections of K/BxN serum every 2–3 weeks, beginning at 8 weeks of age. Arthritis severity was assessed weekly via clinical score. Data are represented as mean ± SEM. Asterisk denotes statistically significant differences: ^#p < 0.001 for ApoE^−/− as compared to control mice. Arrows indicate time of injections