| FGFR1 | FGFR2 | FGFR3 | FGFR4 |
---|---|---|---|---|
Mean histoscore [95Â % CI] | Mean histoscore [95Â % CI] | Mean histoscore [95Â % CI] | Mean histoscore [95Â % CI] | |
Normal vs. cancer | ||||
 Normal | 35 [27–42] | 32 [23–40] | 106 [89–124] | 68 [57–80] |
 Cancer | 84 [77–91] | 70 [64–77] | 82 [76–87] | 129 [122–136] |
 P value | <0.001 | <0.001 | 0.02 | <0.001 |
Stage | ||||
 IB1/IIA | 82 [75–90] | 72 [64–79] | 83 [76–89] | 130 [121–138] |
 IB2/IIB | 89 [70–107] | 66 [48–83] | 79 [65–93] | 117 [97–136] |
 P value | 0.520 | 0.520 | 0.630 | 0.220 |
Cell type | ||||
 SCC | 78 [71–86] | 77 [69–85] | 89 [82–96] | 133 [124–141] |
 AD/ASC | 99 [83–115] | 51 [40–62] | 59 [48–71] | 113 [98–128] |
 P value | 0.020 | <0.001 | <0.001 | 0.020 |
Tumor size | ||||
 ≤4 cm | 85 [77–93] | 74 [667–83] | 83 [76–90] | 131 [122–139] |
 >4 cm | 79 [64–91] | 59 [47–70] | 79 [68–89] | 120 [105–134] |
 P value | 0.330 | 0.020 | 0.500 | 0.210 |
LVSI | ||||
 Negative | 84 [75–93] | 73 [64–82] | 84 [76–93] | 137 [127–147] |
 Positive | 82 [71–93] | 67 [57–77] | 78 [70–87] | 114 [104–126] |
 P value | 0.770 | 0.390 | 0.330 | 0.004 |
Depth of invasion | ||||
 <50 % | 88 [75–101] | 73 [60–86] | 85 [74–97] | 132 [118–146] |
 >50 % | 81 [73–90] | 70 [62–78] | 80 [73–87] | 126 [117–135] |
 P value | 0.420 | 0.670 | 0.490 | 0.470 |
LN metastasis | ||||
 Negative | 83 [75–91] | 74 [66–82] | 84 [77–91] | 132 [124–141] |
 Positive | 84 [70–98] | 60 [48–72] | 75 [65–83] | 114 [98–129] |
 P value | 0.920 | 0.048 | 0.160 | 0.040 |
PM involvement | ||||
 Negative | 85 [78–93] | 73 [66–80] | 83 [77–90] | 129 [121–137] |
 Positive | 65 [48–82] | 49 [34–64] | 64 [50–78] | 115 [91–139] |
 P value | 0.030 | 0.005 | 0.010 | 0.250 |
Resection margin | ||||
 Negative | 83 [76–90] | 71 [64–78] | 82 [76–88] | 128 [121–136] |
 Positive | 88 [50–127] | 70 [42–99] | 80 [52–108] | 118 [75–161] |
 P value | 0.780 | 0.970 | 0.890 | 0.620 |
Primary treatment | ||||
 OP only | 84 [74–94] | 81 [70–91] | 91 [81–100] | 136 [125–147] |
 OP + RT | 81 [66–96] | 67 [53–81] | 73 [62–85] | 127 [111–143] |
 OP + CCRT | 83 [70–96] | 54 [45–64] | 71 [62–81] | 115 [100–129] |
 Neoadjuvant | 86 [2–171] | 96 [17–175] | 96 [20–173] | 119 [38–199] |
 P value | 0.990 | 0.051 | 0.120 | 0.180 |