Table 4 Specific genetic alterations in TP53 gene detected in the five SCLC PDXs

TKO-001

c.422G>A[p.Cys141Tyr]

COSM131470

Missense mutation

TKO-002

c.488A>G[p.Tyr163Cys]

COSM10808

Listed in COSMIC and dbSNP (rs148924904), evidence in COSMIC for being somatic

TKO-003

c.913A>T[p.Lys305Ter]

COSM43773

Stop (Ter) Hemizygous, deletion of one copy

TKO-005

c.488A>G[p.Tyr163Cys]

COSM10808

Listed in COSMIC and dbSNP (rs148924904), evidence in COSMIC for being somatic

TKO-008

c.892G>T[p.Glu298Ter]

COSM10710

Stop (Ter) 80 % of reads