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Table 1 Patient characteristics and summary of treatment efficacy

From: Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer

Variable

Level

N = 20

%

Gender

F

7

35.0

M

13

65.0

Race

White

16

80.0

Black

4

20.0

Age (years)

Mean

63.40 (10.67)

 
 

Median

63 (48–84)

 

Age (years)

<65

10

50.0

≥65

10

50.0

ECOG performance status

0

2

10

1

13

65

2

5

25

No of prior therapies

1a

6

30

2b

6

30

3c

7

35

4d

1

5

Best response

PD

15

88.2

SD

2

11.8

Time to progression (TTP)

Mean

6.26 (3.9)

 

Median

7 (1–17)

 
  1. aPlatinum/etoposide; platinum etoposide/XRT, platinum/etoposide/GDC-049
  2. bTopotecan, oral etoposide, platinum/irinotecan, platinum/etoposide, topotecan/aflibercept; gemcitabine, paclitaxel
  3. cPlatinum etoposide, platinum/irinotecan, topotecan, irinotecan
  4. dIrinotecan