Fig. 6
Characterization of multifunctional (MF) S. Typhi-specific CD8+ TEM responses after challenge. Flow cytometry data were analyzed as described in Fig. 5. Percentages were measured at day 7 for NoTD participants (d7) and at 48 h after typhoid diagnosis (TD + 48 h) for TD participants. a Shown are the percentages of single positive cells (1+) or of total MF cells. b Total MF cells were divided into four groups on the basis of the number of biomarkers they expressed. c The six major individual populations of MF in NoTD participants are represented at baseline (orange) or 7 days after the challenge (dark green). Horizontal lines represent the median for each group. Statistical analyses were performed using mixed effects models to account for multiple observations per person. *p < 0.05, **p < 0.01, ***p < 0.001